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Given that targeted genetic therapies are primarily applicable to the minority fALS cases, a major strategic imperative is to develop interventions for the overarching pathological processes common to both fALS and sALS

These occur because GLP-1 receptor activation slows gastric emptying and changes digestive signaling throughout the gut

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While the branded product was voluntarily discontinued by the manufacturer for commercial reasons (not safety concerns), sermorelin continues to be widely prescribed through compounding pharmacies for off-label therapeutic applications (3)

Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients